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Spillover of antibiotic resistance at the human-food animal interface
Spillover of antibiotic resistance at the human-food animal interface
A major interest of the lab is the impact of antibiotic use in food animals on the selection and spread of resistant pathogens to humans. Previously, Dr. Nadimpalli has examined spill-over of pig-origin, multidrug-resistant Staph aureus to food production workers and their household members in North Carolina. More recently, the lab has been exploring the circular transmission of multidrug-resistant Enterobacteriaceae (and the mobile resistance elements they harbor) between humans and animals in middle-income countries, where intensive animal production that relies on routine antibiotic use is expanding. The role of wet markets in the amplification and spread of AMR pathogens is an ongoing interest.
Nadimpalli ML, Pickering AJ. A call for global monitoring of WASH in wet markets. Lancet Planet Health. 2020 Oct;4(10):e439-e440. [link]
Nadimpalli ML, Stegger M, Viau R, et al. Plugging the leaks: antibiotic resistance at human–animal interfaces in low-resource settings. Front Ecol Environ 2023 . [link]
Nadimpalli M, Yith V, de Lauzanne A, et al. Meat and fish as sources of extended-spectrum B-lactamase-producing Escherichia coli, Cambodia. Emerg Infect Dis 2019; 25(1). [link]
Nadimpalli M, Delarocque-Astagneau E, Love DC, et al. Combating Global Antibiotic Resistance: Emerging One Health Concerns in Lower and Middle-Income Countries (Editor's Choice). Clin Infect Dis. 2018;66(6):963-969. doi:10.1093/cid/cix879. [link]
Role of the gut microbiome in conferring protection against multidrug-resistant pathogens
Role of the gut microbiome in conferring protection against multidrug-resistant pathogens
Currently, we are exploring how differences in the gut microbiome might underlie children's differential susceptibility to gut-colonization with multidrug-resistant pathogens that are otherwise widely present in low-resource settings, including in contaminated food, drinking water, and household soil. We are especially interested in the role that breastfeeding and human milk could play in preventing the establishment, proliferation, and/or selection of antimicrobial-resistant bacteria among young children via modifications to the gut environment, a relatively unexplored topic:
Nadimpalli M, Rojas Salvatierra L, et al. Effects of breastfeeding on children’s gut colonization with multidrug-resistant Enterobacterales in peri-urban Lima, Peru. Gut Microbes. 2024. [link]
Nadimpalli M, Lanza VF, et al. Drinking water chlorination has minor effects on the intestinal flora and resistomes of Bangladeshi children. Nat Microbiol. 2022; 7, 620–629 . [link]
Nadimpalli M, Bourke CD, et al. Can breastfeeding protect against antimicrobial resistance? BMC Med 2020; 18: 392. https://doi.org/10.1186/s12916-020-01862-w. [link]
Antibiotic resistance and inequality
Antibiotic resistance and inequality
The most vulnerable groups in our society - including racial and ethnic minorities and the economically disadvantaged - might also be most at risk of exposure to drug-resistant pathogens. Global changes in climate, urbanization, food production, and income inequality could worsen disparities unless we begin to identify and address them now. We are working with clinicians, spatial scientists, and wastewater surveillance experts to explore the scale, scope, and underlying factors driving racial and ethnic disparities in community-acquired, drug-resistant infections in the United States and globally:
Avendano E, Blackmon SA, Naguneri N, .... Nadimpalli M. Race and ethnicity as risk factors for colonization and infection with key bacterial pathogens: a scoping review. medRxiv 2024.04.24.24306289. [link]
Blackmon SA, Avendano E, Naguneri N, .... Nadimpalli M. Socioeconomic status and the risk for colonization or infection with priority bacterial pathogens: a global evidence map. medRxiv 2024.04.24.24306293. [link]
Alsoubani M, Nadimpalli M, Doron S. How Should Health Care Respond to Threats Antimicrobial Resistance Poses to Workers? AMA J Ethics. 2024;26(5):E383-389. [link]
Nadimpalli M, Chan C, Doron S. Antibiotic resistance: A call to action to prevent the next epidemic of inequality. Nat Med. 2021 Feb;27(2):187-188. [link]
Nadimpalli ML, Marks S, Montealegre MC, et al. Urban informal settlements as hotspots of antimicrobial resistance and the need to curb environmental transmission. Nat Microbiol. 2020;5, 787–795. doi: https://doi.org/10.1038/s41564-020-0722-0 [link]. Editorial titled "Antimicrobial resistance in the age of COVID-19" about this publication: [link]
AMR in ATL Inforgaphic Final.pdfThe above infographic were designed by Shayna Matson (MPH '24) and shared with the City of Atlanta and Fulton County during a May 2024 report-back session at Emory.
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